This package has been designed to help understand whether your molecule is fit for purpose by generating a predicted hepatic clearance, volume of distribution and half-life. These parameters are essential to determine during an early stage drug screening cascade.

Description of Service
Predicted clearance, distribution and half-life in pre-clinical species and/or man using GastroPlus™

Data collected

  • LogD7.4
  • pKa
  • Blood:plasma ratio, Hepatocyte CLint, PPB (for each species)

Report format
XenoGesis will generate a written report together with a simulated concentration-time profile from 1mg/kg IV bolus dose for each species.

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