Oral Exposure

This package has been designed to predict the oral exposure of a molecule. It will evaluate the fraction of dose that is likely to be absorbed, how much it is distributed, what the predicted hepatic clearance and its half-life is. It also builds in the predicted plasma concentration time of a single PO dose and oral bioavailability, Cmax and Tmax at this dose level.

Description of Service
Prediction of plasma exposure following oral dosing using GastroPlus™

Data collected

  • Caco-2 permeability
  • Solubility in buffer and biorelevant media (thermodynamic – ideally PBS@ pH6.5, FeSSIF, FaSSIF and SGF)
  • LogD7.4
  • pKa
  • Blood:plasma ratio, Hepatocyte CLint, PPB (for each species)

Report format
A written report will be generated with predicted hepatic clearance, volume of distribution, half-life and simulated concentration-time profile from 1mg/kg IV bolus dose for each species. Additionally, the report will include the predicted plasma concentration-time profile from single PO dose and oral bioavailability, Cmax and Tmax at the PO dose level.

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