Absorption

Understanding whether your oral drug is likely to be absorbed is the first step in understanding the bioavailability of the compound. XenoGesis has designed this package to provide the key information when assessing the likely absorption of a drug and how this is expected to vary with dose.

Description of Service
Preliminary assessment of absorption potential following an oral dose using GastroPlus™

Data collected

  • Caco-2 permeability
  • Thermodynamic solubility in buffer and biorelevant media
  • pKa

Report format
XenoGesis will provide a written report which plots the predicted percentage of drug absorbed in rat, dog and human across typical dose ranges (1-300 mg/kg in rat and dog and 1-1000mg in man).

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