DMPK Modelling and Simulation Senior Scientist – PK/PD

Nottingham, Cheshire or UK home based
Competitive salary and benefits
Permanent, full time, 36.25 hrs per week

XenoGesis is looking for an exceptional DMPK Modelling and Simulation Senior Scientist to support client projects from early discovery stages through to clinical trials. The successful applicant will be responsible for the modelling and simulation strategy for all client projects. This will include developing, implementing and validating PK and PK-PD models using pre-clinical in vitro and in vivo data with the ultimate aim of providing a robust prediction of human pharmacokinetics and efficacious dose.

The successful applicant will be involved in the mentoring and training of other members within the group as well as building the modelling and simulation team in line with the development of the business.

This role can be located either in Nottingham, Cheshire or home based within the UK.


  • Our ideal candidate will either have a BSc, MSc or PhD in pharmacometrics, pharmaceutical sciences, engineering, mathematics or systems biology
  • At least 5 years industrial experience in the use of modelling and simulation to support drug discovery
  • Excellent understanding of theory, principles and statistical aspects of advanced mathematical modelling and simulation
  • Thorough understanding of the basic principles of pharmacokinetics and experience in the use of pre-clinical data for human efficacious dose prediction
  • Proficient in the use of software and applications in the area of PKPD modelling and simulation (e.g. Phoenix, MATLAB, Berkeley-Madonna, R, NONMEM or comparable applications)
  • Experience in PBPK modelling software, such as GastroPlus, SimCYP or PK-Sim
  • Develop/code and validate mathematical PK-PD/Biomarker/Efficacy models to elucidate the quantitative PK-PD relationships in pre-clinical species
  • Good written and verbal communication skills with the ability to summarise outcomes in a clear and concise manner

Salary & benefits:

XenoGesis offers a competitive salary with a great range of benefits to include 25 days annual leave plus 8 bank holidays, company sick pay, annual bonus based on targets, work place pension scheme, life assurance, cycle to work scheme, modern laboratories and offices in the heart of Nottingham.


Founded in 2011, XenoGesis has grown to over 30 employees and is now the UK’s largest independent laboratory-based contract research organisation, specialising in preclinical drug metabolism and pharmacokinetics (DMPK). We have recently moved to state of the art lab and office space and continue to invest in the latest cutting-edge technology, ensuring the best possible service for our global client base. We are based in BioCity in Nottingham.


If you’re interested in applying for this position, please email your CV and covering letter, quoting the job title to: